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A Distribution-Based Multiple Imputation Method for Handling Bivariate Pesticide Data with Values below the Limit of Detection

Author: Chen, Haiying
Date Published: 2011

Environmental and biomedical researchers frequently encounter laboratory data constrained by a lower limit of detection (LOD). Commonly used methods to address these left-censored data, such as simple substitution of a constant for all values < LOD, may bias parameter estimation. In contrast, multiple imputation (MI) methods yields valid and robust parameter estimates and explict imputed values for variables that can be analyzed as outcomes or predictors. In this article, they expand distribution-based MI methods for left-censored data to a bivariate setting, specifically, a longitudinal study with biological measures at two points in time.

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Number of Pages: 6