Association Between Human Paraoxonase Gene Polymorphism and Chronic Symptoms in Pesticide-Exposed Workers
Author: Lee, Burton W.
Date Published: 2003
This journal article explains the role of paraoxonase (paN) in organophosphate metabolism and the implications of polymorphism in the human pan gene for farm workers exposed to pesticides. Through an epidemiological survey of deciduous fruit farm workers in Western Cape, South Africa, the study found that symptoms consistent with chronic organophosphate toxicity was significantly more likely among subjects with the slow (GIn/GIn or GIn/Arg) PONgenotypes compared to those with the fast (Arg/ Arg) PO N genotype.
Date Published: 2003
This journal article explains the role of paraoxonase (paN) in organophosphate metabolism and the implications of polymorphism in the human pan gene for farm workers exposed to pesticides. Through an epidemiological survey of deciduous fruit farm workers in Western Cape, South Africa, the study found that symptoms consistent with chronic organophosphate toxicity was significantly more likely among subjects with the slow (GIn/GIn or GIn/Arg) PONgenotypes compared to those with the fast (Arg/ Arg) PO N genotype.
